Drug interactions
Darolutamide + Itraconazole
Severity: Moderate
Darolutamide and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide is a substrate of CYP3A4 and P-gp, and itraconazole inhibits both, raising darolutamide exposure. This may increase adverse effects such as fatigue, and rarely cardiac events.
What this interaction means in plain words
Darolutamide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits CYP3A4 and P-glycoprotein, reducing darolutamide clearance.
What to do
Monitor for darolutamide adverse reactions, and reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Itraconazole?
MediHelp rates the interaction as moderate. Darolutamide and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide is a substrate of CYP3A4 and P-gp, and itraconazole inhibits both, raising darolutamide exposure. This may increase adverse effects such as fatigue, and rarely cardiac events.
How serious is the interaction between Darolutamide and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide adverse reactions, and reduce the dose if toxicity occurs.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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