Drug interactions
Darolutamide + Moxifloxacin
Severity: Moderate
Darolutamide and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Androgen deprivation can prolong the QT interval and moxifloxacin is a recognized QT-prolonging fluoroquinolone. Combined use may increase the risk of torsades de pointes.
What this interaction means in plain words
Darolutamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Moxifloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation; moxifloxacin blocks hERG potassium channels and androgen deprivation may prolong repolarization.
What to do
Consider a non-QT-prolonging antibiotic where feasible. If used together, check the ECG and correct potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darolutamide and Moxifloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Darolutamide
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Darolutamide with Moxifloxacin?
MediHelp rates the interaction as moderate. Darolutamide and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Androgen deprivation can prolong the QT interval and moxifloxacin is a recognized QT-prolonging fluoroquinolone. Combined use may increase the risk of torsades de pointes.
How serious is the interaction between Darolutamide and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a non-QT-prolonging antibiotic where feasible. If used together, check the ECG and correct potassium and magnesium.
What other medicines interact with Darolutamide?
MediHelp also lists interactions of Darolutamide with, for example, Apalutamide, Carbamazepine, Efavirenz. The full list is on the Darolutamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
