Drug interactions
Darolutamide + Nitrofurantoin
Severity: Moderate
Darolutamide and Nitrofurantoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, a transporter that nitrofurantoin may use for efflux. Exposure to nitrofurantoin could increase, though the clinical effect is not well characterized.
What this interaction means in plain words
Darolutamide and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Nitrofurantoin belongs to Anti Bacterial.
Why it happens
Inhibition of BCRP-mediated efflux, which may increase nitrofurantoin exposure.
What to do
Monitor for nitrofurantoin adverse effects such as nausea, neuropathy and pulmonary symptoms during prolonged therapy. Prefer short courses and review renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darolutamide and Nitrofurantoin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Nitrofurantoin
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Nitrofurantoin?
MediHelp rates the interaction as moderate. Darolutamide and Nitrofurantoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, a transporter that nitrofurantoin may use for efflux. Exposure to nitrofurantoin could increase, though the clinical effect is not well characterized.
How serious is the interaction between Darolutamide and Nitrofurantoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for nitrofurantoin adverse effects such as nausea, neuropathy and pulmonary symptoms during prolonged therapy. Prefer short courses and review renal function.
What other medicines interact with Nitrofurantoin?
MediHelp also lists interactions of Nitrofurantoin with, for example, Pexidartinib, Pretomanid, Aluminum hydroxide. The full list is on the Nitrofurantoin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
