Drug interactions
Darolutamide + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Darolutamide and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP and P-gp, which handle velpatasvir, voxilaprevir and sofosbuvir. Exposure to the HCV drugs may rise. The clinical effect is likely modest but has been flagged in labeling.
What this interaction means in plain words
Darolutamide and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Darolutamide inhibits BCRP and P-gp efflux, which increases HCV drug absorption.
What to do
Monitor for adverse effects of the HCV regimen such as headache and fatigue, or consider an alternative if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Darolutamide and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP and P-gp, which handle velpatasvir, voxilaprevir and sofosbuvir. Exposure to the HCV drugs may rise. The clinical effect is likely modest but has been flagged in labeling.
How serious is the interaction between Darolutamide and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects of the HCV regimen such as headache and fatigue, or consider an alternative if tolerability is poor.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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