Drug interactions
Darunavir + Dutasteride-tamsulosin
Severity: Major
Darunavir and Dutasteride-tamsulosin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can increase tamsulosin concentrations. Hypotension and syncope may result.
What this interaction means in plain words
Darunavir and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Dutasteride-tamsulosin belongs to Genitourinary.
Why it happens
CYP3A4 inhibition (enhanced by the booster) reduces tamsulosin clearance.
What to do
Avoid if possible and use an alternative BPH agent. If used together, monitor blood pressure and counsel on orthostatic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dutasteride-tamsulosin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Dutasteride-tamsulosin?
MediHelp rates the interaction as major. Darunavir and Dutasteride-tamsulosin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and can increase tamsulosin concentrations. Hypotension and syncope may result.
How serious is the interaction between Darunavir and Dutasteride-tamsulosin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and use an alternative BPH agent. If used together, monitor blood pressure and counsel on orthostatic symptoms.
What other medicines interact with Dutasteride-tamsulosin?
MediHelp also lists interactions of Dutasteride-tamsulosin with, for example, Alfuzosin, Amifostine, Atazanavir. The full list is on the Dutasteride-tamsulosin page.
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