Drug interactions
Darunavir + Eszopiclone
Severity: Moderate
Darunavir and Eszopiclone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and increases eszopiclone exposure. This raises the risk of excessive sedation and next-day impairment.
What this interaction means in plain words
Darunavir and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Eszopiclone belongs to Central Nervous System.
Why it happens
Boosted darunavir inhibits CYP3A4-mediated metabolism of eszopiclone.
What to do
Limit the eszopiclone starting dose to 1 mg and a maximum of 2 mg; monitor for oversedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Eszopiclone?
MediHelp rates the interaction as moderate. Darunavir and Eszopiclone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and increases eszopiclone exposure. This raises the risk of excessive sedation and next-day impairment.
How serious is the interaction between Darunavir and Eszopiclone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the eszopiclone starting dose to 1 mg and a maximum of 2 mg; monitor for oversedation.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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