Drug interactions
Darunavir + Flutamide
Severity: Moderate
Darunavir and Flutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may increase flutamide exposure. Flutamide carries a boxed warning for hepatotoxicity, so higher exposure is undesirable.
What this interaction means in plain words
Darunavir and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Flutamide belongs to Endocrine.
Why it happens
CYP3A4 inhibition by darunavir and its booster reduces flutamide metabolism.
What to do
Monitor liver function tests regularly and stop flutamide if transaminases rise markedly or jaundice occurs. Consider a different antiandrogen if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flutamide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Flutamide?
MediHelp rates the interaction as moderate. Darunavir and Flutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may increase flutamide exposure. Flutamide carries a boxed warning for hepatotoxicity, so higher exposure is undesirable.
How serious is the interaction between Darunavir and Flutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests regularly and stop flutamide if transaminases rise markedly or jaundice occurs. Consider a different antiandrogen if possible.
What other medicines interact with Flutamide?
MediHelp also lists interactions of Flutamide with, for example, Idelalisib, Levoketoconazole, Pexidartinib. The full list is on the Flutamide page.
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