Drug interactions
Darunavir + Fluticasone-vilanterol
Severity: Moderate
Darunavir and Fluticasone-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise fluticasone furoate and vilanterol exposure. This may cause systemic corticosteroid effects including adrenal suppression, and beta-agonist effects such as palpitations and hypokalemia.
What this interaction means in plain words
Darunavir and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated metabolism of fluticasone furoate and vilanterol.
What to do
Monitor for Cushingoid features, adrenal suppression and cardiovascular beta-agonist effects. Consider an alternative inhaled corticosteroid such as beclometasone for long-term use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluticasone-vilanterol
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Fluticasone-vilanterol?
MediHelp rates the interaction as moderate. Darunavir and Fluticasone-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise fluticasone furoate and vilanterol exposure. This may cause systemic corticosteroid effects including adrenal suppression, and beta-agonist effects such as palpitations and hypokalemia.
How serious is the interaction between Darunavir and Fluticasone-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for Cushingoid features, adrenal suppression and cardiovascular beta-agonist effects. Consider an alternative inhaled corticosteroid such as beclometasone for long-term use.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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