Drug interactions
Darunavir + Formoterol-mometasone
Severity: Major
Darunavir and Formoterol-mometasone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster such as ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise mometasone exposure. This increases the risk of systemic corticosteroid effects such as Cushing's syndrome and adrenal suppression.
What this interaction means in plain words
Darunavir and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Formoterol-mometasone belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated mometasone metabolism, particularly with boosted regimens.
What to do
Consider switching to an inhaled corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term use. If combined, monitor for Cushingoid signs and adrenal suppression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Formoterol-mometasone?
MediHelp rates the interaction as major. Darunavir and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, inhibits CYP3A4 and can substantially raise mometasone exposure. This increases the risk of systemic corticosteroid effects such as Cushing's syndrome and adrenal suppression.
How serious is the interaction between Darunavir and Formoterol-mometasone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider switching to an inhaled corticosteroid less dependent on CYP3A4, such as beclomethasone, for long-term use. If combined, monitor for Cushingoid signs and adrenal suppression.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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