Drug interactions
Darunavir + Lidocaine-prilocaine
Severity: Minor
Darunavir and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with a booster, can inhibit CYP3A4 and may increase lidocaine exposure. For topical lidocaine-prilocaine at standard doses the systemic impact is likely small, but extensive application could raise the risk of toxicity.
What this interaction means in plain words
Darunavir and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Darunavir (and its booster) inhibits CYP3A4-mediated metabolism of lidocaine.
What to do
Limit the application area and duration of the cream. Monitor for CNS or cardiac symptoms of lidocaine toxicity if large or repeated doses are needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Darunavir and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually given with a booster, can inhibit CYP3A4 and may increase lidocaine exposure. For topical lidocaine-prilocaine at standard doses the systemic impact is likely small, but extensive application could raise the risk of toxicity.
How serious is the interaction between Darunavir and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the application area and duration of the cream. Monitor for CNS or cardiac symptoms of lidocaine toxicity if large or repeated doses are needed.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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