Drug interactions
Darunavir + Memantine-donepezil
Severity: Moderate
Darunavir and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may raise donepezil levels. This can increase cholinergic effects including bradycardia, syncope and gastrointestinal symptoms, and donepezil can also prolong the QT interval.
What this interaction means in plain words
Darunavir and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Boosted darunavir inhibits CYP3A4, reducing donepezil clearance.
What to do
Monitor heart rate, ECG if risk factors exist, and cholinergic adverse effects. Consider reducing the donepezil dose if these effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Memantine-donepezil?
MediHelp rates the interaction as moderate. Darunavir and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may raise donepezil levels. This can increase cholinergic effects including bradycardia, syncope and gastrointestinal symptoms, and donepezil can also prolong the QT interval.
How serious is the interaction between Darunavir and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, ECG if risk factors exist, and cholinergic adverse effects. Consider reducing the donepezil dose if these effects develop.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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