Drug interactions
Darunavir + Mifepristone
Severity: Major
Darunavir and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted, strongly inhibits CYP3A4 and increases mifepristone exposure, and mifepristone may raise darunavir levels. This raises the risk of adverse effects such as QT prolongation, hypokalemia and adrenal insufficiency.
What this interaction means in plain words
Darunavir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Mifepristone belongs to Endocrine.
Why it happens
Mutual inhibition of CYP3A4-mediated metabolism.
What to do
Cap mifepristone at 300 mg/day for Cushing syndrome with strong CYP3A4 inhibitors. Monitor potassium, ECG and antiretroviral toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Darunavir and Mifepristone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Mifepristone?
MediHelp rates the interaction as major. Darunavir and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually boosted, strongly inhibits CYP3A4 and increases mifepristone exposure, and mifepristone may raise darunavir levels. This raises the risk of adverse effects such as QT prolongation, hypokalemia and adrenal insufficiency.
How serious is the interaction between Darunavir and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Cap mifepristone at 300 mg/day for Cushing syndrome with strong CYP3A4 inhibitors. Monitor potassium, ECG and antiretroviral toxicity.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
