Drug interactions
Darunavir + Nicardipine
Severity: Moderate
Darunavir and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and may substantially increase nicardipine levels. This may lead to marked hypotension, tachycardia and edema.
What this interaction means in plain words
Darunavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Nicardipine belongs to Cardiovascular.
Why it happens
Boosted darunavir inhibits CYP3A4 and reduces first-pass and systemic clearance of nicardipine.
What to do
Start nicardipine at a low dose and titrate to blood pressure response; monitor heart rate and blood pressure. Consider an alternative antihypertensive if exposure is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Nicardipine?
MediHelp rates the interaction as moderate. Darunavir and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4 and may substantially increase nicardipine levels. This may lead to marked hypotension, tachycardia and edema.
How serious is the interaction between Darunavir and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start nicardipine at a low dose and titrate to blood pressure response; monitor heart rate and blood pressure. Consider an alternative antihypertensive if exposure is excessive.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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