Drug interactions
Darunavir + Prednisone
Severity: Moderate
Darunavir and Prednisone: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, normally boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise prednisolone exposure. Prolonged coadministration may produce Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Darunavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Prednisone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated prednisolone metabolism by boosted darunavir.
What to do
Use the lowest effective prednisone dose and monitor for Cushingoid features, hyperglycemia and adrenal suppression. For long-term therapy consider an alternative steroid or antiretroviral.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- Darunavir - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Prednisone?
MediHelp rates the interaction as moderate. Darunavir and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, normally boosted with ritonavir or cobicistat, inhibits CYP3A4 and can raise prednisolone exposure. Prolonged coadministration may produce Cushingoid effects and adrenal suppression.
How serious is the interaction between Darunavir and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prednisone dose and monitor for Cushingoid features, hyperglycemia and adrenal suppression. For long-term therapy consider an alternative steroid or antiretroviral.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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