Drug interactions
Darunavir + Quetiapine
Severity: Major
Darunavir and Quetiapine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is usually given with ritonavir or cobicistat, which are strong CYP3A4 inhibitors, and this raises quetiapine concentrations considerably. This increases the risk of oversedation, hypotension and QT prolongation.
What this interaction means in plain words
Darunavir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Quetiapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated quetiapine metabolism by the boosted protease inhibitor regimen.
What to do
Reduce the quetiapine dose substantially when starting a boosted darunavir regimen, and monitor sedation, blood pressure and ECG. Increase the dose again if the inhibitor is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Quetiapine?
MediHelp rates the interaction as major. Darunavir and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir is usually given with ritonavir or cobicistat, which are strong CYP3A4 inhibitors, and this raises quetiapine concentrations considerably. This increases the risk of oversedation, hypotension and QT prolongation.
How serious is the interaction between Darunavir and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the quetiapine dose substantially when starting a boosted darunavir regimen, and monitor sedation, blood pressure and ECG. Increase the dose again if the inhibitor is stopped.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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