Drug interactions
Darunavir + Ritonavir
Severity: Moderate
Darunavir and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir substantially increases darunavir exposure, which is required for its efficacy and is an intended boosting strategy. Excess exposure could increase hepatic and gastrointestinal adverse effects.
What this interaction means in plain words
Darunavir and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4, decreasing darunavir first-pass and systemic metabolism.
What to do
Give darunavir only with low-dose ritonavir at labeled doses. Monitor liver function and tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Ritonavir?
MediHelp rates the interaction as moderate. Darunavir and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir substantially increases darunavir exposure, which is required for its efficacy and is an intended boosting strategy. Excess exposure could increase hepatic and gastrointestinal adverse effects.
How serious is the interaction between Darunavir and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give darunavir only with low-dose ritonavir at labeled doses. Monitor liver function and tolerability.
What other medicines interact with Ritonavir?
MediHelp also lists interactions of Ritonavir with, for example, Alfuzosin, Amiodarone, Avanafil. The full list is on the Ritonavir page.
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