Drug interactions
Darunavir + Saxagliptin-metformin
Severity: Moderate
Darunavir and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is usually given with a booster (ritonavir or cobicistat), which strongly inhibits CYP3A4 and markedly raises saxagliptin exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of metformin.
What this interaction means in plain words
Darunavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Boosted darunavir inhibits CYP3A4, reducing saxagliptin clearance, and protease inhibitors can induce insulin resistance.
What to do
Limit the saxagliptin dose to 2.5 mg daily with strong CYP3A4 inhibitors, which requires using separate components rather than the fixed combination. Monitor blood glucose regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Darunavir and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir is usually given with a booster (ritonavir or cobicistat), which strongly inhibits CYP3A4 and markedly raises saxagliptin exposure. Protease inhibitors can also cause insulin resistance and hyperglycemia, which may reduce the effect of metformin.
How serious is the interaction between Darunavir and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit the saxagliptin dose to 2.5 mg daily with strong CYP3A4 inhibitors, which requires using separate components rather than the fixed combination. Monitor blood glucose regularly.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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