Drug interactions
Darunavir + Tinidazole
Severity: Minor
Darunavir and Tinidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase tinidazole exposure. Tinidazole adverse effects such as nausea, metallic taste and neurological symptoms may become more frequent.
What this interaction means in plain words
Darunavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Tinidazole belongs to Anti Parasitic.
Why it happens
Inhibition of CYP3A4 reduces tinidazole clearance.
What to do
Standard tinidazole courses can generally be given; monitor for adverse effects, especially with prolonged courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tinidazole
- Disulfiram + Tinidazole Contraindicated
- Ethanol + Tinidazole Major
- Fexinidazole + Tinidazole Major
- Lopinavir + Tinidazole Major
- Nilotinib + Tinidazole Major
- Ritonavir + Tinidazole Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Tinidazole?
MediHelp rates the interaction as minor. Darunavir and Tinidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase tinidazole exposure. Tinidazole adverse effects such as nausea, metallic taste and neurological symptoms may become more frequent.
How serious is the interaction between Darunavir and Tinidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Standard tinidazole courses can generally be given; monitor for adverse effects, especially with prolonged courses.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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