Drug interactions
Darunavir + Vardenafil
Severity: Major
Darunavir and Vardenafil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and markedly increases vardenafil exposure. This raises the risk of hypotension, syncope, visual changes and prolonged erection.
What this interaction means in plain words
Darunavir and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Vardenafil belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated vardenafil metabolism by darunavir and its booster.
What to do
Do not exceed the reduced labeled vardenafil dose and interval, and monitor blood pressure and adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Vardenafil?
MediHelp rates the interaction as major. Darunavir and Vardenafil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Boosted darunavir inhibits CYP3A4 and markedly increases vardenafil exposure. This raises the risk of hypotension, syncope, visual changes and prolonged erection.
How serious is the interaction between Darunavir and Vardenafil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not exceed the reduced labeled vardenafil dose and interval, and monitor blood pressure and adverse effects.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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