Drug interactions
Darunavir + Warfarin
Severity: Moderate
Darunavir and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is given with ritonavir or cobicistat, and the net effect on warfarin is unpredictable, with INR possibly rising or falling. Changes in anticoagulation control can cause bleeding or clotting.
What this interaction means in plain words
Darunavir and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Warfarin belongs to Cardiovascular.
Why it happens
Boosted darunavir regimens have mixed CYP inhibition and induction effects on warfarin enantiomer metabolism, so the net effect is variable.
What to do
Monitor INR closely when starting or stopping darunavir-based therapy and adjust the warfarin dose according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Warfarin?
MediHelp rates the interaction as moderate. Darunavir and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir is given with ritonavir or cobicistat, and the net effect on warfarin is unpredictable, with INR possibly rising or falling. Changes in anticoagulation control can cause bleeding or clotting.
How serious is the interaction between Darunavir and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR closely when starting or stopping darunavir-based therapy and adjust the warfarin dose according to results.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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