Drug interactions
Darunavir + Zafirlukast
Severity: Minor
Darunavir and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir is metabolized by CYP3A4 and is normally boosted with ritonavir or cobicistat, which already inhibit this enzyme strongly. Adding weakly inhibiting zafirlukast is unlikely to cause a meaningful further rise.
What this interaction means in plain words
Darunavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Zafirlukast belongs to Respiratory.
Why it happens
Weak CYP3A4 inhibition by zafirlukast could slightly reduce darunavir clearance.
What to do
No dose change is needed; continue routine monitoring of HIV treatment tolerability and viral load.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Zafirlukast?
MediHelp rates the interaction as minor. Darunavir and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir is metabolized by CYP3A4 and is normally boosted with ritonavir or cobicistat, which already inhibit this enzyme strongly. Adding weakly inhibiting zafirlukast is unlikely to cause a meaningful further rise.
How serious is the interaction between Darunavir and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; continue routine monitoring of HIV treatment tolerability and viral load.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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