Drug interactions
Dasatinib + Duvelisib
Severity: Moderate
Dasatinib and Duvelisib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib is a moderate CYP3A4 inhibitor and can increase dasatinib exposure, raising the risk of dasatinib adverse effects such as myelosuppression and fluid retention.
What this interaction means in plain words
Dasatinib and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibition of CYP3A4 reduces dasatinib clearance.
What to do
Monitor blood counts and signs of toxicity, and consider reducing the dasatinib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Dasatinib with Duvelisib?
MediHelp rates the interaction as moderate. Dasatinib and Duvelisib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Duvelisib is a moderate CYP3A4 inhibitor and can increase dasatinib exposure, raising the risk of dasatinib adverse effects such as myelosuppression and fluid retention.
How serious is the interaction between Dasatinib and Duvelisib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of toxicity, and consider reducing the dasatinib dose.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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