Drug interactions
Dasatinib + Ibutilide
Severity: Major
Dasatinib and Ibutilide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibutilide is a class III antiarrhythmic with a high risk of torsades de pointes, and dasatinib also prolongs the QT interval. Together they greatly increase the risk of a life-threatening arrhythmia.
What this interaction means in plain words
Dasatinib and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ibutilide belongs to Cardiovascular.
Why it happens
Additive QT prolongation through potassium channel blockade and related repolarization effects.
What to do
Avoid the combination and consider electrical cardioversion or another rhythm strategy. If it cannot be avoided, give ibutilide with continuous ECG monitoring and corrected electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Ibutilide
- Amiodarone + Ibutilide Contraindicated
- Amisulpride + Ibutilide Contraindicated
- Chlorpromazine + Ibutilide Contraindicated
- Clarithromycin + Ibutilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Dolasetron + Ibutilide Contraindicated
Frequently asked questions
Can I take Dasatinib with Ibutilide?
MediHelp rates the interaction as major. Dasatinib and Ibutilide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibutilide is a class III antiarrhythmic with a high risk of torsades de pointes, and dasatinib also prolongs the QT interval. Together they greatly increase the risk of a life-threatening arrhythmia.
How serious is the interaction between Dasatinib and Ibutilide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and consider electrical cardioversion or another rhythm strategy. If it cannot be avoided, give ibutilide with continuous ECG monitoring and corrected electrolytes.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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