Drug interactions
Dasatinib + Lapatinib
Severity: Moderate
Dasatinib and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, and lapatinib is a CYP3A4 substrate that dasatinib may weakly inhibit. Together they may increase risk of arrhythmia and lapatinib toxicity.
What this interaction means in plain words
Dasatinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Lapatinib belongs to Oncology.
Why it happens
Additive QT prolongation with weak CYP3A4 inhibition by dasatinib.
What to do
Monitor ECG and electrolytes, and watch for lapatinib toxicity such as diarrhea and hepatotoxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Dasatinib with Lapatinib?
MediHelp rates the interaction as moderate. Dasatinib and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs prolong the QT interval, and lapatinib is a CYP3A4 substrate that dasatinib may weakly inhibit. Together they may increase risk of arrhythmia and lapatinib toxicity.
How serious is the interaction between Dasatinib and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, and watch for lapatinib toxicity such as diarrhea and hepatotoxicity.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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