Drug interactions
Dasatinib + Lenacapavir
Severity: Moderate
Dasatinib and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor and may increase dasatinib exposure, with the effect persisting for months after subcutaneous dosing. This may increase dasatinib toxicity.
What this interaction means in plain words
Dasatinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Lenacapavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 metabolism of dasatinib by lenacapavir.
What to do
Monitor for dasatinib adverse effects including cytopenias, effusions and QTc, and consider a dasatinib dose reduction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dasatinib with Lenacapavir?
MediHelp rates the interaction as moderate. Dasatinib and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor and may increase dasatinib exposure, with the effect persisting for months after subcutaneous dosing. This may increase dasatinib toxicity.
How serious is the interaction between Dasatinib and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dasatinib adverse effects including cytopenias, effusions and QTc, and consider a dasatinib dose reduction.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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