Drug interactions
Dasatinib + Mifepristone
Severity: Major
Dasatinib and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase dasatinib exposure, raising the risk of myelosuppression, fluid retention and QT prolongation. Mifepristone also has its own QT liability.
What this interaction means in plain words
Dasatinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4, reducing dasatinib metabolism, with additive QT effects.
What to do
Prefer an alternative to mifepristone. If coadministered, reduce the dasatinib dose per labeling, and monitor blood counts and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Mifepristone?
MediHelp rates the interaction as major. Dasatinib and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone may increase dasatinib exposure, raising the risk of myelosuppression, fluid retention and QT prolongation. Mifepristone also has its own QT liability.
How serious is the interaction between Dasatinib and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to mifepristone. If coadministered, reduce the dasatinib dose per labeling, and monitor blood counts and ECG.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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