Drug interactions
Dasatinib + Nicardipine
Severity: Minor
Dasatinib and Nicardipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may slightly raise nicardipine exposure. The effect is usually small, but hypotension or edema could be more pronounced.
What this interaction means in plain words
Dasatinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Nicardipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by dasatinib decreases nicardipine clearance.
What to do
Monitor blood pressure and edema after starting dasatinib and reduce nicardipine dose if needed. Be aware dasatinib can also cause fluid retention.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nicardipine
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Nicardipine?
MediHelp rates the interaction as minor. Dasatinib and Nicardipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and may slightly raise nicardipine exposure. The effect is usually small, but hypotension or edema could be more pronounced.
How serious is the interaction between Dasatinib and Nicardipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and edema after starting dasatinib and reduce nicardipine dose if needed. Be aware dasatinib can also cause fluid retention.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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