Drug interactions
Dasatinib + Primaquine
Severity: Moderate
Dasatinib and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval and their combination may increase the risk of torsades de pointes. Dasatinib can also cause cytopenias, and primaquine can cause hemolysis, so hematologic effects may overlap.
What this interaction means in plain words
Dasatinib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Primaquine belongs to Anti Parasitic.
Why it happens
Additive QTc prolongation through pharmacodynamic effects.
What to do
Perform a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG and blood counts during combined use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Primaquine?
MediHelp rates the interaction as moderate. Dasatinib and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval and their combination may increase the risk of torsades de pointes. Dasatinib can also cause cytopenias, and primaquine can cause hemolysis, so hematologic effects may overlap.
How serious is the interaction between Dasatinib and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform a baseline ECG and correct hypokalemia and hypomagnesemia. Monitor ECG and blood counts during combined use.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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