Drug interactions
Dasatinib + Propafenone
Severity: Major
Dasatinib and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval and propafenone has proarrhythmic effects on cardiac conduction. Using both increases the likelihood of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Dasatinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Propafenone belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction.
What to do
Avoid the combination when possible. If both are necessary, correct hypokalemia and hypomagnesemia first and monitor the ECG regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Propafenone?
MediHelp rates the interaction as major. Dasatinib and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib can prolong the QT interval and propafenone has proarrhythmic effects on cardiac conduction. Using both increases the likelihood of serious ventricular arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Dasatinib and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If both are necessary, correct hypokalemia and hypomagnesemia first and monitor the ECG regularly.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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