Drug interactions
Dasatinib + Ritonavir
Severity: Major
Dasatinib and Ritonavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and can considerably raise dasatinib exposure. This increases the risk of myelosuppression, fluid retention, bleeding and QT prolongation.
What this interaction means in plain words
Dasatinib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4-mediated dasatinib metabolism by ritonavir.
What to do
Use an alternative antiretroviral without strong CYP3A4 inhibition if possible. Otherwise reduce the dasatinib dose and monitor blood counts, ECG and fluid status.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Dasatinib with Ritonavir?
MediHelp rates the interaction as major. Dasatinib and Ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir is a strong CYP3A4 inhibitor and can considerably raise dasatinib exposure. This increases the risk of myelosuppression, fluid retention, bleeding and QT prolongation.
How serious is the interaction between Dasatinib and Ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative antiretroviral without strong CYP3A4 inhibition if possible. Otherwise reduce the dasatinib dose and monitor blood counts, ECG and fluid status.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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