Drug interactions
Dasatinib + Saxagliptin-metformin
Severity: Minor
Dasatinib and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak, time-dependent CYP3A4 inhibitor and could slightly raise saxagliptin concentrations. Clinical impact is expected to be small because saxagliptin has a wide margin of safety.
What this interaction means in plain words
Dasatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition reduces saxagliptin metabolism.
What to do
No dose adjustment is generally required; monitor glucose routinely.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Dasatinib and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak, time-dependent CYP3A4 inhibitor and could slightly raise saxagliptin concentrations. Clinical impact is expected to be small because saxagliptin has a wide margin of safety.
How serious is the interaction between Dasatinib and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is generally required; monitor glucose routinely.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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