Drug interactions
Dasatinib + Vardenafil
Severity: Moderate
Dasatinib and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib prolongs the QT interval and weakly inhibits CYP3A4, while vardenafil also has a QT effect. The combination may add arrhythmia risk, especially with electrolyte disturbance.
What this interaction means in plain words
Dasatinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Vardenafil belongs to Genitourinary.
Why it happens
Additive QT prolongation, with possible weak CYP3A4 inhibition raising vardenafil levels.
What to do
Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with cardiac risk factors. Use the lowest effective vardenafil dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Vardenafil?
MediHelp rates the interaction as moderate. Dasatinib and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib prolongs the QT interval and weakly inhibits CYP3A4, while vardenafil also has a QT effect. The combination may add arrhythmia risk, especially with electrolyte disturbance.
How serious is the interaction between Dasatinib and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and obtain an ECG in patients with cardiac risk factors. Use the lowest effective vardenafil dose.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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