Drug interactions
Dasatinib + Verapamil
Severity: Moderate
Dasatinib and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak inhibitor of CYP3A4 and may modestly raise verapamil exposure. Verapamil is itself a moderate CYP3A4 inhibitor and may raise dasatinib concentrations. Either change may increase adverse effects such as bradycardia, hypotension, or myelosuppression and fluid retention.
What this interaction means in plain words
Dasatinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Mutual CYP3A4 inhibition, with verapamil as a moderate inhibitor and dasatinib as a weak inhibitor, raises exposure to both drugs' substrates.
What to do
Monitor heart rate, blood pressure and PR interval, and watch for dasatinib toxicity such as cytopenias and pleural effusion. Reduce the dasatinib dose or choose a non-inhibiting antihypertensive if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dasatinib and Verapamil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Verapamil?
MediHelp rates the interaction as moderate. Dasatinib and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak inhibitor of CYP3A4 and may modestly raise verapamil exposure. Verapamil is itself a moderate CYP3A4 inhibitor and may raise dasatinib concentrations. Either change may increase adverse effects such as bradycardia, hypotension, or myelosuppression and fluid retention.
How serious is the interaction between Dasatinib and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and PR interval, and watch for dasatinib toxicity such as cytopenias and pleural effusion. Reduce the dasatinib dose or choose a non-inhibiting antihypertensive if toxicity develops.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
