Drug interactions
Dasatinib + Vonoprazan
Severity: Moderate
Dasatinib and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan strongly and durably suppresses gastric acid, which reduces dissolution and absorption of dasatinib tablets. This may lower dasatinib exposure and compromise efficacy.
What this interaction means in plain words
Dasatinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Sustained elevation of gastric pH decreases absorption of pH-dependent dasatinib.
What to do
Avoid long-term acid suppression with vonoprazan if possible; a short-acting antacid given 2 hours apart is an alternative. If it is needed, monitor molecular response to dasatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dasatinib and Vonoprazan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Dasatinib with Vonoprazan?
MediHelp rates the interaction as moderate. Dasatinib and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan strongly and durably suppresses gastric acid, which reduces dissolution and absorption of dasatinib tablets. This may lower dasatinib exposure and compromise efficacy.
How serious is the interaction between Dasatinib and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term acid suppression with vonoprazan if possible; a short-acting antacid given 2 hours apart is an alternative. If it is needed, monitor molecular response to dasatinib.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
