Drug interactions
Dasatinib + Voxelotor
Severity: Moderate
Dasatinib and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 and can increase exposure to sensitive substrates such as dasatinib. Higher dasatinib levels may increase myelosuppression, effusions and QT prolongation.
What this interaction means in plain words
Dasatinib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Inhibition of CYP3A4-mediated metabolism of dasatinib by voxelotor.
What to do
Avoid if possible; otherwise consider reducing the dasatinib dose and monitor blood counts and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Dasatinib with Voxelotor?
MediHelp rates the interaction as moderate. Dasatinib and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 and can increase exposure to sensitive substrates such as dasatinib. Higher dasatinib levels may increase myelosuppression, effusions and QT prolongation.
How serious is the interaction between Dasatinib and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise consider reducing the dasatinib dose and monitor blood counts and ECG.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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