Drug interactions
Dasatinib + Warfarin
Severity: Major
Dasatinib and Warfarin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib impairs platelet function and can cause thrombocytopenia, increasing the bleeding risk in patients taking warfarin. INR changes have also been reported.
What this interaction means in plain words
Dasatinib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect from dasatinib-induced platelet dysfunction and cytopenia combined with vitamin K antagonism.
What to do
Monitor INR and platelet counts closely and watch for bleeding. Consider an alternative anticoagulant if platelet counts are low.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Warfarin?
MediHelp rates the interaction as major. Dasatinib and Warfarin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib impairs platelet function and can cause thrombocytopenia, increasing the bleeding risk in patients taking warfarin. INR changes have also been reported.
How serious is the interaction between Dasatinib and Warfarin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR and platelet counts closely and watch for bleeding. Consider an alternative anticoagulant if platelet counts are low.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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