Drug interactions
Dasatinib + Zidovudine
Severity: Moderate
Dasatinib and Zidovudine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib commonly causes neutropenia, anemia and thrombocytopenia, and zidovudine adds to these effects. The combination may result in clinically significant cytopenias.
What this interaction means in plain words
Dasatinib and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Zidovudine belongs to Anti Virals.
Why it happens
Additive bone marrow suppression.
What to do
Monitor full blood counts regularly, and adjust or interrupt dasatinib or zidovudine for significant cytopenias. Consider an alternative antiretroviral if cytopenias develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Zidovudine?
MediHelp rates the interaction as moderate. Dasatinib and Zidovudine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib commonly causes neutropenia, anemia and thrombocytopenia, and zidovudine adds to these effects. The combination may result in clinically significant cytopenias.
How serious is the interaction between Dasatinib and Zidovudine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor full blood counts regularly, and adjust or interrupt dasatinib or zidovudine for significant cytopenias. Consider an alternative antiretroviral if cytopenias develop.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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