Drug interactions
Dasatinib + Ziprasidone
Severity: Major
Dasatinib and Ziprasidone: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone has a clear QT-prolonging effect and dasatinib can also prolong the QT interval, so the combination raises the risk of torsades de pointes. Ziprasidone is contraindicated with other QT-prolonging drugs per labeling.
What this interaction means in plain words
Dasatinib and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT interval prolongation.
What to do
Avoid the combination where possible and choose a less QT-active antipsychotic. If unavoidable, correct electrolytes and monitor ECG closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ziprasidone?
MediHelp rates the interaction as major. Dasatinib and Ziprasidone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ziprasidone has a clear QT-prolonging effect and dasatinib can also prolong the QT interval, so the combination raises the risk of torsades de pointes. Ziprasidone is contraindicated with other QT-prolonging drugs per labeling.
How serious is the interaction between Dasatinib and Ziprasidone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a less QT-active antipsychotic. If unavoidable, correct electrolytes and monitor ECG closely.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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