Drug interactions
Daunorubicin + Eliglustat
Severity: Moderate
Daunorubicin and Eliglustat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein, and daunorubicin is a P-gp substrate. Raised daunorubicin levels could increase myelosuppression, mucositis and cardiotoxicity.
What this interaction means in plain words
Daunorubicin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Eliglustat belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition reduces efflux of daunorubicin and increases its exposure.
What to do
Monitor blood counts and cardiac status closely. Reduce the daunorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Daunorubicin with Eliglustat?
MediHelp rates the interaction as moderate. Daunorubicin and Eliglustat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein, and daunorubicin is a P-gp substrate. Raised daunorubicin levels could increase myelosuppression, mucositis and cardiotoxicity.
How serious is the interaction between Daunorubicin and Eliglustat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status closely. Reduce the daunorubicin dose if toxicity occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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