Drug interactions
Daunorubicin + Eluxadoline
Severity: Minor
Daunorubicin and Eluxadoline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP in vitro and may increase exposure to BCRP substrates. Daunorubicin is a possible substrate of efflux transporters, so exposure could rise modestly, but clinical significance is uncertain.
What this interaction means in plain words
Daunorubicin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daunorubicin belongs to Oncology; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Eluxadoline inhibits BCRP transporter, possibly reducing efflux of daunorubicin; clinical relevance is not established.
What to do
No dose change is required; monitor blood counts and cardiac status during daunorubicin therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Daunorubicin with Eluxadoline?
MediHelp rates the interaction as minor. Daunorubicin and Eluxadoline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits BCRP in vitro and may increase exposure to BCRP substrates. Daunorubicin is a possible substrate of efflux transporters, so exposure could rise modestly, but clinical significance is uncertain.
How serious is the interaction between Daunorubicin and Eluxadoline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor blood counts and cardiac status during daunorubicin therapy.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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