Drug interactions
Daunorubicin + Itraconazole
Severity: Moderate
Daunorubicin and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase daunorubicin exposure by blocking its efflux. This could increase myelosuppression, mucositis and cardiotoxicity.
What this interaction means in plain words
Daunorubicin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Itraconazole belongs to Anti Fungals.
Why it happens
Itraconazole inhibits P-glycoprotein, reducing the efflux and clearance of daunorubicin.
What to do
Monitor blood counts and cardiac function and consider a daunorubicin dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Itraconazole?
MediHelp rates the interaction as moderate. Daunorubicin and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase daunorubicin exposure by blocking its efflux. This could increase myelosuppression, mucositis and cardiotoxicity.
How serious is the interaction between Daunorubicin and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function and consider a daunorubicin dose reduction if toxicity develops.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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