Drug interactions
Daunorubicin + Ivacaftor
Severity: Moderate
Daunorubicin and Ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and may raise levels of P-gp substrates. Daunorubicin toxicity such as myelosuppression could be increased, though clinical data are lacking.
What this interaction means in plain words
Daunorubicin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Ivacaftor belongs to Miscellaneous.
Why it happens
Ivacaftor inhibits P-gp-mediated efflux of daunorubicin.
What to do
Monitor blood counts and cardiac function; reduce daunorubicin dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Ivacaftor
- Ensitrelvir + Ivacaftor Contraindicated
- Apalutamide + Ivacaftor Major
- Carbamazepine + Ivacaftor Major
- Clarithromycin + Ivacaftor Major
- Efavirenz + Ivacaftor Major
- Enzalutamide + Ivacaftor Major
Frequently asked questions
Can I take Daunorubicin with Ivacaftor?
MediHelp rates the interaction as moderate. Daunorubicin and Ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivacaftor and its M1 metabolite weakly inhibit P-glycoprotein and may raise levels of P-gp substrates. Daunorubicin toxicity such as myelosuppression could be increased, though clinical data are lacking.
How serious is the interaction between Daunorubicin and Ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function; reduce daunorubicin dose if toxicity occurs.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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