Drug interactions
Daunorubicin + Lasmiditan
Severity: Moderate
Daunorubicin and Lasmiditan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lasmiditan inhibits P-gp and BCRP in vitro, and daunorubicin is a substrate of these efflux transporters. Exposure to daunorubicin could rise, though clinical data are lacking.
What this interaction means in plain words
Daunorubicin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Lasmiditan belongs to Central Nervous System.
Why it happens
Inhibition of P-gp and BCRP efflux transporters may increase daunorubicin exposure.
What to do
Consider an alternative acute migraine therapy on days of daunorubicin dosing. Monitor blood counts and cardiac function if used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Lasmiditan
- Alprazolam + Lasmiditan Moderate
- Amiodarone + Lasmiditan Moderate
- Amisulpride + Lasmiditan Moderate
- Amobarbital + Lasmiditan Moderate
- Aripiprazole + Lasmiditan Moderate
- Asenapine + Lasmiditan Moderate
Frequently asked questions
Can I take Daunorubicin with Lasmiditan?
MediHelp rates the interaction as moderate. Daunorubicin and Lasmiditan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lasmiditan inhibits P-gp and BCRP in vitro, and daunorubicin is a substrate of these efflux transporters. Exposure to daunorubicin could rise, though clinical data are lacking.
How serious is the interaction between Daunorubicin and Lasmiditan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative acute migraine therapy on days of daunorubicin dosing. Monitor blood counts and cardiac function if used together.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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