Drug interactions
Daunorubicin + Tacrolimus
Severity: Moderate
Daunorubicin and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus can inhibit P-glycoprotein, which helps clear daunorubicin from cells and the body. Exposure to the anthracycline may rise, increasing the risk of myelosuppression, mucositis and cardiotoxicity. Clinical data are limited.
What this interaction means in plain words
Daunorubicin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Tacrolimus inhibits P-glycoprotein-mediated efflux of daunorubicin, potentially increasing its tissue and systemic exposure.
What to do
Monitor blood counts and signs of anthracycline toxicity, including cardiac function, when the two are used together. Keep tacrolimus trough levels and renal function under review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Daunorubicin with Tacrolimus?
MediHelp rates the interaction as moderate. Daunorubicin and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus can inhibit P-glycoprotein, which helps clear daunorubicin from cells and the body. Exposure to the anthracycline may rise, increasing the risk of myelosuppression, mucositis and cardiotoxicity. Clinical data are limited.
How serious is the interaction between Daunorubicin and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and signs of anthracycline toxicity, including cardiac function, when the two are used together. Keep tacrolimus trough levels and renal function under review.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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