Drug interactions
Decitabine + Hydroxycarbamide
Severity: Moderate
Decitabine and Hydroxycarbamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs suppress the bone marrow, so combined use can worsen cytopenias. This raises the risk of infection and bleeding, though the combination is sometimes used deliberately in myeloid malignancies.
What this interaction means in plain words
Decitabine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Decitabine belongs to Oncology; Hydroxycarbamide belongs to Oncology.
Why it happens
Additive myelosuppression from hypomethylating activity and ribonucleotide reductase inhibition.
What to do
Monitor complete blood counts frequently and adjust doses according to cytopenias. Provide supportive care and infection prophylaxis as appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Decitabine
Other interactions of Hydroxycarbamide
- Didanosine + Hydroxycarbamide Contraindicated
- Hydroxycarbamide + Stavudine Contraindicated
- Adenovirus types 4 and 7 live + Hydroxycarbamide Major
- Axicabtagene ciloleucel + Hydroxycarbamide Major
- Bcg intravesical live + Hydroxycarbamide Major
- Bcg vaccine live + Hydroxycarbamide Major
Frequently asked questions
Can I take Decitabine with Hydroxycarbamide?
MediHelp rates the interaction as moderate. Decitabine and Hydroxycarbamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs suppress the bone marrow, so combined use can worsen cytopenias. This raises the risk of infection and bleeding, though the combination is sometimes used deliberately in myeloid malignancies.
How serious is the interaction between Decitabine and Hydroxycarbamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and adjust doses according to cytopenias. Provide supportive care and infection prophylaxis as appropriate.
What other medicines interact with Decitabine?
MediHelp also lists interactions of Decitabine with, for example, Dengue vaccine, Etrasimod, Fingolimod. The full list is on the Decitabine page.
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