Drug interactions
Mitotane + Montelukast
Severity: Moderate
Mitotane and Montelukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane is a strong, long-lasting inducer of CYP3A4 and may lower montelukast concentrations. This could reduce asthma or allergic rhinitis control, and the effect persists for weeks after mitotane is stopped.
What this interaction means in plain words
Mitotane and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mitotane belongs to Oncology; Montelukast belongs to Respiratory.
Why it happens
Mitotane induces CYP3A4 and other hepatic enzymes, increasing montelukast clearance.
What to do
Monitor asthma control and consider additional or alternative controller therapy if symptoms worsen; remember induction persists after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Montelukast
- Apalutamide + Montelukast Moderate
- Carbamazepine + Montelukast Moderate
- Deferasirox + Montelukast Moderate
- Enzalutamide + Montelukast Moderate
- Fosphenytoin + Montelukast Moderate
- Gemfibrozil + Montelukast Moderate
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Mitotane with Montelukast?
MediHelp rates the interaction as moderate. Mitotane and Montelukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane is a strong, long-lasting inducer of CYP3A4 and may lower montelukast concentrations. This could reduce asthma or allergic rhinitis control, and the effect persists for weeks after mitotane is stopped.
How serious is the interaction between Mitotane and Montelukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma control and consider additional or alternative controller therapy if symptoms worsen; remember induction persists after mitotane discontinuation.
What other medicines interact with Montelukast?
MediHelp also lists interactions of Montelukast with, for example, Apalutamide, Carbamazepine, Deferasirox. The full list is on the Montelukast page.
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