Drug interactions
Deferasirox + Ticlopidine
Severity: Major
Deferasirox and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause gastrointestinal ulceration and hemorrhage. Combined with ticlopidine, which impairs platelet function, the risk of serious GI bleeding is increased.
What this interaction means in plain words
Deferasirox and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic risk: mucosal injury from deferasirox plus P2Y12 platelet inhibition by ticlopidine.
What to do
Monitor for GI bleeding symptoms and hemoglobin, and consider gastroprotection. Avoid the combination in patients with low platelet counts or prior GI hemorrhage.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ticlopidine
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ticlopidine?
MediHelp rates the interaction as major. Deferasirox and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause gastrointestinal ulceration and hemorrhage. Combined with ticlopidine, which impairs platelet function, the risk of serious GI bleeding is increased.
How serious is the interaction between Deferasirox and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding symptoms and hemoglobin, and consider gastroprotection. Avoid the combination in patients with low platelet counts or prior GI hemorrhage.
What other medicines interact with Ticlopidine?
MediHelp also lists interactions of Ticlopidine with, for example, Mavacamten, Abrocitinib, Acetylsalicylic acid. The full list is on the Ticlopidine page.
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