Drug interactions
Deferiprone + Ferric maltol
Severity: Moderate
Deferiprone and Ferric maltol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone chelates iron, so it can bind the iron delivered by ferric maltol in the gut and reduce its absorption, defeating the purpose of iron replacement. The two drugs have opposing therapeutic aims and are rarely appropriate together.
What this interaction means in plain words
Deferiprone and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Ferric maltol belongs to Miscellaneous.
Why it happens
Deferiprone forms stable complexes with ferric iron in the gastrointestinal tract, limiting iron absorption.
What to do
Avoid combining where possible, as they have opposing goals. If both are given, separate doses by at least 4 hours and monitor ferritin and hemoglobin.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Ferric maltol
- Aluminum hydroxide + Ferric maltol Moderate
- Calcium carbonate + Ferric maltol Moderate
- Calcium + Ferric maltol Moderate
- Carbidopa-entacapone-levodopa + Ferric maltol Moderate
- Carbidopa-levodopa + Ferric maltol Moderate
- Cimetidine + Ferric maltol Moderate
Frequently asked questions
Can I take Deferiprone with Ferric maltol?
MediHelp rates the interaction as moderate. Deferiprone and Ferric maltol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone chelates iron, so it can bind the iron delivered by ferric maltol in the gut and reduce its absorption, defeating the purpose of iron replacement. The two drugs have opposing therapeutic aims and are rarely appropriate together.
How serious is the interaction between Deferiprone and Ferric maltol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible, as they have opposing goals. If both are given, separate doses by at least 4 hours and monitor ferritin and hemoglobin.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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