Drug interactions
Deferoxamine + Prochlorperazine
Severity: Moderate
Deferoxamine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of deferoxamine with phenothiazines such as prochlorperazine has been associated with transient impairment of consciousness, including coma, when given with high-dose IV vitamin C and prochlorperazine. Evidence is limited, but the labelled warning applies to this combination.
What this interaction means in plain words
Deferoxamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferoxamine belongs to Miscellaneous; Prochlorperazine belongs to Central Nervous System.
Why it happens
Mechanism is not well established.
What to do
Monitor mental status during deferoxamine infusion in patients taking prochlorperazine, and stop the infusion if consciousness declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Deferoxamine
Frequently asked questions
Can I take Deferoxamine with Prochlorperazine?
MediHelp rates the interaction as moderate. Deferoxamine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of deferoxamine with phenothiazines such as prochlorperazine has been associated with transient impairment of consciousness, including coma, when given with high-dose IV vitamin C and prochlorperazine. Evidence is limited, but the labelled warning applies to this combination.
How serious is the interaction between Deferoxamine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor mental status during deferoxamine infusion in patients taking prochlorperazine, and stop the infusion if consciousness declines.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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