Drug interactions
Defibrotide + Flurbiprofen
Severity: Moderate
Defibrotide and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic activity and may enhance the effects of drugs that affect hemostasis, such as NSAIDs that inhibit platelets. Concurrent use may increase the risk of bleeding.
What this interaction means in plain words
Defibrotide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect on hemostasis, with defibrotide's profibrinolytic action combined with NSAID platelet inhibition.
What to do
Monitor for signs of bleeding and review whether the NSAID is necessary during defibrotide therapy. Consider an alternative analgesic such as paracetamol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Flurbiprofen?
MediHelp rates the interaction as moderate. Defibrotide and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic activity and may enhance the effects of drugs that affect hemostasis, such as NSAIDs that inhibit platelets. Concurrent use may increase the risk of bleeding.
How serious is the interaction between Defibrotide and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and review whether the NSAID is necessary during defibrotide therapy. Consider an alternative analgesic such as paracetamol.
What other medicines interact with Flurbiprofen?
MediHelp also lists interactions of Flurbiprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Flurbiprofen page.
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